Demethylation of a specific hypersensitive site in the Th2 locus control region
نویسندگان
چکیده
منابع مشابه
Demethylation of a specific hypersensitive site in the Th2 locus control region.
A growing body of literature has examined and implicated DNA methylation as a critical epigenetic modification in T helper (Th) cell differentiation. The absence of DNA methyltransferases or methyl-binding proteins derepresses many cytokine loci, allowing their ectopic expression, while methylation of specific CpG residues is sufficient to prevent expression. Here, we characterize demethylation...
متن کاملHypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.
The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass the regulatory core of the LCR. To determine the function of these sites, mutan...
متن کاملDirect interaction of NF-E2 with hypersensitive site 2 of the beta-globin locus control region in living cells.
The human beta-globin locus control region (LCR) confers high-level, tissue-specific expression to the beta-globin genes. Tandem Maf recognition elements (MAREs) within the hypersensitive site 2 (HS2) subregion of the LCR are important for the strong enhancer activity of the LCR. Multiple proteins are capable of interacting with these sites in vitro, including the erythroid cell- and megakaryoc...
متن کاملthe relationship between locus of control and iranian efl university students’ beliefs about language learning
this exploratory study aimed to investigate a possible relationship between learners’ beliefs about language learning and one of their personality traits; that is,locus of control (loc). both variables, beliefs and locus of control, are assumed to influence the language learning process. the internal control index (ici) and the beliefs about language learning inventory (balli) were administered...
Description and Targeted Deletion of 5 8 Hypersensitive Site 5 and 6 of the Mouse b - Globin Locus Control Region
The most upstream hypersensitive site (HS) of the b-globin locus control region (LCR) in humans (58 HS 5) and chickens (58 HS 4) can act as an insulating element in some gain of function assays and may demarcate a b-globin domain. We have mapped the most upstream HSs of the mouse b-globin LCR and sequenced this region. We find that mice have a region homologous to human 58 HS 5 that is associat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0708293104